This is a global and multi-annual space-borne data set of tropospheric {H2O,δD} pairs based on radiance measurements from the nadir thermal infrared sensor IASI (Infrared Atmospheric Sounding Interferometer) onboard the Metop satellites of EUMETSAT (European Organisation for the Exploitation of Meteorological Satellites). The data set is an a posteriori processed extension of the MUSICA (MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water) IASI full product dataset distributed as MUSICA IASI full retrieval product. The a posteriori processing guarantees H2O and δD states having almost identical and good vertical sensitivities, i.e. can be used as a {H2O,δD} pair data product.